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Abbott Introduces Biothreat Assay for PLEX-ID™ System


Abbott announced today that it has introduced the PLEX-ID™ Biothreat Assay, which is designed to detect and distinguish 17 different biothreat pathogens. This assay enables rapid and accurate detection of potentially dangerous microorganisms that could pose serious threats to human health, food, water and other resources.

"While public health officials concerned with bioterrorism and emerging infectious diseases are detecting known, conventional infectious agents, it's becoming very clear there is a need for broader detection and characterization of pathogens for biodefense," said David Ecker, Ph.D., divisional vice president and general manager, of Abbott's Ibis Biosciences subsidiary. "The PLEX-ID system's new biothreat assay will serve that need by identifying and quantifying, for non-diagnostic purposes, a broad set of pathogens including bacteria and families of viruses in humans and animals."

The PLEX-ID Biothreat Assay permits analysis of direct specimens, such as blood, water, food and air filter samples, and provides results in less than eight hours. Seventeen different bioagents are targeted in the new test, including Bacillus anthracis, E. coli, salmonella, ebola virus, and avian influenza viruses. PLEX-ID offers the unique capability to detect and identify these, and other, bacterial and viral biothreat agents while also differentiating similar organisms.

The PLEX-ID system can perform identification and typing of expected and unknown microorganisms from direct specimens, which saves time while providing critical information without the need to grow the agent in culture first. Currently intended for non-diagnostic use, PLEX-ID is the only high-throughput technology that offers rapid and broad identification, detailed genotyping and characterization, and recognition of emerging organisms. The system employs a combination of molecular technologies, including polymerase chain reaction (PCR) for gene amplification and mass spectrometry analysis to rapidly characterize known and unknown organisms.

PLEX-ID is designed to identify a broad range of bacteria, viruses, fungi, certain parasites, and also provide information about drug resistance, virulence, and strain type. Anticipated public health and biodefense applications include epidemiologic research and identification of emerging or previously unknown agents. In addition, the system is being used for forensic characterization of human samples.

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