Taking up on the pioneering work published by the Japanese scientists around Prof. Sadaaki Iwanaga, the test developers at Hyglos have been able to finalize an improved recombinant Factor C (rFC) assay.
Recombinant factor C, which is the essential part of EndoZyme® , is the endotoxin-specific principal receptor in the LAL enzyme cascade. In the assay recombinant Factor C is activated by any endotoxin present in the sample, recombinant Factor C enzymatically cleaves a synthetic substrate resulting in a fluorescence signal.
EndoZyme® at a glance:
- Improved sensitivity and measurement range 0.005 EU/ml to 50 EU/ml
- Excellent correlation to LAL
- No false-positive glucan reaction due to endotoxin-specific recombinant technology
- Reliability and lot-to-lot consistency
- No animal material, therefore saving the diminishing horseshoe crab population
About Hyglos and its Endotoxin Detection products:
Hyglos core competency is to exploit its proprietary phage-ligand technology in developing test solutions for research, manufacturing and clinical applications. With the 2011 introduction of EndoLISA® , the world’s first commercially available solid-phase based method for endotoxin detection, Hyglos paved the way for a new era in endotoxin testing. Thanks to its heterogeneous assay format, EndoLISA® is particularly suited for complex sample matrices. With the launch of EndoZyme® , Hyglos now also offers a homogeneous test format suitable for all less demanding samples.
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